Buy valium online,overnight discount

Brand name:Valium injection
Pharmacology

Anxiolytic - Sedative

Diazepam is an anxiolytic-sedative drug useful in the symptomatic relief of anxiety and tension states. It has also adjunctive value in the relief of certain neurospastic conditions and in certain cases, its anticonvulsant activity has been found useful in controlling status epilepticus.

Peak blood levels after the i.v. administration of diazepam injection are reached within 15 minutes as compared to 1 hour after a single oral dosing and are of the same magnitude. The acute half-life is 2 to 3 hours with a slower decline thereafter, possibly due to tissue storage. Repeated doses further increase blood levels. In humans, comparable blood levels of diazepam injection were obtained in maternal and cord blood indicating rapid placental transfer of the drug.
Indications

In the symptomatic management of mild to moderate degrees of anxiety in conditions dominated by tension, excitation, agitation, fear or aggressiveness, such as may occur in: Psychoneurosis; anxiety reactions due to stressful conditions; and anxiety states with somatic expression.

Diazepam is indicated parenterally when a rapid response is desired and has been found useful: In acute anxiety or tension states related to stressful conditions or non-psychotic emotional disorders; to alleviate the symptoms of acute alcoholic withdrawal, including delirium tremens; as an adjunct in relieving anxiety states that may be present before minor surgical procedures or prior to esophagoscopy and gastroscopy (when used under conditions in which resuscitative measures are available); to control prolonged seizure activity (status epilepticus) including severe recurrent seizures (see Precautions); for the relief of muscle spasm in cerebral palsy, athetosis, the rare stiff man syndrome and adjunctively in tetanus; as premedication for relief of anxiety states prior to surgical procedures (i.m. route) or cardioversion (i.v. route).
Dosage

Valium Roche Injection is used without diluent for both the i.m. and i.v. routes. The i.m. route should be preferred whenever the indication and urgency of the clinical situation permit. The i.m. route is indicated when diazepam injection is used as premedication to relieve anxiety states prior to surgical procedures (usually 30 to 45 minutes before the procedure. The i.v. route is indicated when diazepam injection is used prior to cardioversion.

While dosage should be individualized for maximum beneficial effect, as a general rule the usual dose for both the i.v. and i.m. routes is: acute anxiety or tension states related to stressful conditions or nonpsychotic emotional disorders: 2 to 10 mg i.m. or i.v. Repeat in 3 to 4 hours, if necessary.

Acute alcoholic withdrawal: to alleviate the symptoms of acute alcoholic withdrawal including delirium tremens: 10 mg i.m. or i.v. initially, then 5 to 10 mg in 3 to 4 hours, if necessary.

Minor surgical procedures including esophagoscopy and gastroscopy: As an adjunct in relieving anxiety states that may be present before these procedures: 5 to 10 mg i.m. or i.v. approximately 30 minutes prior to procedures.

For the relief of muscle spasm in cerebral palsy, athetosis, the rare “stiff man syndrome” and adjunctively in tetanus: 5 to 10 mg i.m. or i.v. initially; then 5 to 10 mg in 3 to 4 hours, if necessary. For tetanus, larger doses may be required.

Status epilepticus including severe recurrent seizures: for the control of prolonged seizure activity: 5 to 10 mg i.v. (preferred route) initially. Repeat in 2 to 4 hours if necessary.

Premedication to surgical procedures: for the relief of anxiety states (if atropine, scopolamine or other premedication are desired, they must be administered in separate syringes): 10 mg i.m. (preferred route), 1 to 2 hours before surgery.

Cardioversion: to relieve anxiety and tension: 5 to 15 mg i.v. within 5 to 10 minutes prior to the procedureChildren: depending on age and severity of symptoms, 2 to 10 mg i.m. or i.v. or 1 mg/4.5 kg.

Elderly and debilitated: (see Precautions and Adverse Effects) 2 to 5 mg i.m. or i.v.

I.M.: Diazepam injection should be injected deeply into the muscle.

I.V.: Diazepam injection should be administered slowly, i.e., 5 mg/minute.

In acute conditions, the injection may be repeated within 1 hour although an interval of 3 to 4 hours is usually satisfactory. Generally not more than 30 mg should be given in an 8 hour period.

I.V. Infusion: (see Warnings). Not more than 40 mg (8 mL of ampul solution) should be added to 500 mL of infusion solution (normal saline or 5% dextrose in water). The solution should be freshly made up and used within 6 hours.

Over 50% of the diazepam in the infusion solution may be adsorbed onto the walls of plastic containers. Therefore, only infusion solutions in glass containers can be administered.

Adsorption onto plastic drip tubing causes an initial significant and variable reduction (up to 40% or more) of delivered diazepam concentration which then gradually rises over the next few hours. The drip rate should be frequently titrated against the patient’s condition.

Bolus allows a more accurate and rapid titration of dosage than slow i.v. infusion. It is therefore to be preferred in the management of acute problems.